Abstract
We present a test-retest dataset of resting-state fMRI data obtained in 80 cognitively normal elderly volunteers enrolled in the “Pre-symptomatic Evaluation of Novel or Experimental Treatments for Alzheimer's Disease” (PREVENT-AD) Cohort. Subjects with a family history of Alzheimer's disease in first-degree relatives were recruited as part of an on-going double blind randomized clinical trial of Naproxen or placebo. Two pairs of scans were acquired ~3 months apart, allowing the assessment of both intra- and inter-session reliability, with the possible caveat of treatment effects as a source of inter-session variation. Using the NeuroImaging Analysis Kit (NIAK), we report on the standard quality of co-registration and motion parameters of the data, and assess their validity based on the spatial distribution of seed-based connectivity maps as well as intra- and inter-session reliability metrics in the default-mode network. This resource, released publicly as sample UM1 of the Consortium for Reliability and Reproducibility (CoRR), will benefit future studies focusing on the preclinical period preceding the appearance of dementia in Alzheimer's disease.
Highlights
The dementia that results from neurodegeneration in Alzheimer's disease (AD) is associated with disruptions in functional brain connectivity[1,2]
These alterations in brain connectivity can be explored in vivo in humans using resting-state functional magnetic resonance imaging, a technique that captures spontaneous brain function[3]
Since the seminal work by Greicius and colleagues[5], research has confirmed that patients who suffer from dementia of AD exhibit connectivity abnormalities, in the default-mode network (DMN)[6,7,8,9,10,11,12,13]
Summary
Background & SummaryThe dementia that results from neurodegeneration in Alzheimer's disease (AD) is associated with disruptions in functional brain connectivity[1,2]. Since the seminal work by Greicius and colleagues[5], research has confirmed that patients who suffer from dementia of AD exhibit connectivity abnormalities, in the default-mode network (DMN)[6,7,8,9,10,11,12,13]. This network includes brain regions that are consistently more active at rest than during a broad range of tasks[14]. Other brain structures are regarded as part of different subnetworks of the DMN, for instance the medial temporal lobe (MTL) or the superior frontal gyrus (SFG)[17,18]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
