Abstract
ObjetivesProgressive loss of bone mineral density weakens the bones and increases the probability of osteoporotic fractures. It is well known that sex steroids play a role in the maintenance of bone density. This fact makes us think there might be a correlation between sex steroid levels and osteoporotic hip fractures. Materials and methodsA case–control study was performed. The cases were 54 men who suffered from hip fracture. They were compared with 54 age-matched male control subjects. Levels of total testosterone, sex hormone binding globuline, albumin and estradiol were measured in all subjects in order to calculate free testosterone and bio-testosterone levels. ResultsMen who suffered from hip fracture had lower serum total testosterone (8.74nmol/l vs. 11.16nmol/l; p=0.116) and lower free testostenone (155.1pmol/l vs. 204.4pmol/l; p=0.02) than control subjects. Bio-testosterone levels were lower in patients with hip fracture (2.69nmol/l vs. 3.89nmol/l; p=0.002), being the latter the best fracture predictor (OR: 1.58). ConclusionsIn our study population, men with hip fractures had significantly lower levels of calculated free testosterone and bio-testosterone. These findings suggest that free testosterone and bio-testosterone levels are independent predictors for osteoporotic hip fracture in elderly men.
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