Abstract
In men, testosterone deficiency may contribute to metabolic syndrome; use of androgen supplements is prevalent in the US, in middle‐aged and elderly men. However, the long term impact of androgen supplements is unknown. In this study, the hypothesis was tested that testosterone supplements will improve metabolic syndrome and blood pressure (BP) in obese male rats. Testosterone supplements (T; 10 mm pellets) were implanted subcutaneously into lean (LZR) and obese (OZR) Zucker rats, and body weight, BP, and oral glucose tolerance tests (OGTT) were performed. Control OZR had higher BP (120±3 vs 104±2mmHg; p<0.01), body weight (BW; 922±23 vs 570±7g; p<0.001), OGTT (926±63 vs 446±20mg/dl*h; p<0.001), than control LZR. T significantly decreased body weight by 21% and improved oral glucose tolerance by 30% compared to control OZR, but did not affect BP. In LZR, T had no effect on BW, BP, or OGTT. These data suggest that chronic T supplements may be beneficial in attenuating the metabolic syndrome in aging men, but does not improve hypertension. This study was supported by HL 69194, HL 66072 and HL 51971 from NIH.
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