Abstract
Type 2 diabetes is linked to premature mortality and considerable morbidity. Its worldwide prevalence has risen substantially in the past four decades due to a mixture of rising obesity and increasing life expectancies, with reductions in premature mortality in type 2 diabetes. Diabetes also seems to be a major risk factor for COVID-19-related death. 1 Barron E Bakhai C Kar P et al. Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: a whole-population study. Lancet Diabetes Endocrinol. 2020; 8: 813-822 Summary Full Text Full Text PDF PubMed Scopus (479) Google Scholar Any novel mechanisms to lessen diabetes development would therefore be helpful. Testosterone treatment to prevent or revert type 2 diabetes in men enrolled in a lifestyle programme (T4DM): a randomised, double-blind, placebo-controlled, 2-year, phase 3b trialTestosterone treatment for 2 years reduced the proportion of participants with type 2 diabetes beyond the effects of a lifestyle programme. Increases in haematocrit might be treatment limiting. Longer-term durability, safety, and cardiovascular effects of the intervention remain to be further investigated. Full-Text PDF
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