Abstract
Abstract Purpose: We analyzed biochemical relapse and sexual function in patients treated for prostate cancer with proton therapy (PT) and later treated with testosterone replacement therapy (TRT) for hypogonadism. Patients and Methods: Twenty-three patients with biopsy-proven, localized prostate cancer were treated with definitive PT at our institution from 2006 to 2012. Each patient had hypogonadal symptoms and low serum testosterone and received TRT after PT. Biochemical failure was defined by the Phoenix criteria. Sexual function was reported using patient-reported data from the Expanded Prostate Cancer Index Composite (EPIC) questionnaire. Rates of sexual potency are also reported. Results: The median follow-up was 38 months after completing PT and 14 months after initiating TRT. After 1 to 6 months on TRT, the median serum testosterone level increased from 238 to 497. No patient experienced biochemical failure. Median prostate-specific antigen did not significantly rise. Median EPIC sexual summary, ...
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