Abstract
Background The Arp2/3 complex is a seven-protein assembly that is critical for actin nucleation and branching in cells. Although some DNA methylation patterns are altered by steroid hormone exposure in the developing brain, less is known about how changes in steroid hormone levels influence Arp2/3 complex DNA methylation patterns in the adult brain. Steroid hormones act in the adult brain to regulate gene expression. Specifically, the expression of the Arp2 within adult brain is dependent upon testosterone exposure.
Highlights
The Arp2/3 complex is a seven-protein assembly that is critical for actin nucleation and branching in cells
Some DNA methylation patterns are altered by steroid hormone exposure in the developing brain, less is known about how changes in steroid hormone levels influence Arp2/3 complex DNA methylation patterns in the adult brain
Steroid hormones act in the adult brain to regulate gene expression
Summary
The Arp2/3 complex is a seven-protein assembly that is critical for actin nucleation and branching in cells. Testosterone regulates Arp2/3 expression by DNA methylation in hippocampus From 2011 International Conference on Molecular Neurodegeneration Shanghai, China. Background The Arp2/3 complex is a seven-protein assembly that is critical for actin nucleation and branching in cells.
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