Abstract
The effects of γ-1,2,3,4,5,6-hexachlorocyclohexane (lindane) and O, O-dimethyl- S-(1,2-dicarbethoxyethyl)phosphorodithioate (malathion) on testosterone metabolism in rat prostate tissue in vitro was investigated. The influence of lindane on the formation of 5α-androstan-17β-ol-3-one (5α-DHT)-receptor complex in the rat prostatic cytosol has also been examined. Lindane and malathion inhibited the formation of 5α-DHT, and lindane caused a decrease in the formation of 5α-androstane-3,17-dione (androstanedione) in the rat prostate tissue. A mixture of lindane and malathion exerted a synergistic effect on testosterone metabolism in the rat prostate, as indicated by lower 5α-DHT and higher 5α-androstane-3α,17β-diol formation. The presence of lindane significantly inhibited 5α-DHT-receptor complex formation in the rat prostatic cytosol, and this inhibition was of a fully noncompetitive type.
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