Abstract
In human studies there is no difference in blood pressure between boys and girls, but following puberty, blood pressure increases more in men than in women suggesting sex-specific differences in blood pressure regulation. Modulation of epithelial sodium reabsorption through the expression and activity of ENaC is an important component in the control of sodium balance. We investigated the androgen-dependent regulation of alpha-ENaC using the human renal cell line HKC-8 as a model.
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