TESTOSTERONE AND SEX HORMONE-BINDING GLOBULIN IN DYSGLYCEMIC WOMEN AT HIGH CARDIOVASCULAR RISK: A REPORT FROM THE OUTCOME REDUCTION WITH AN INITIAL GLARGINE INTERVENTION TRIAL

Anne Wang,Stefan Arver,Kurt Boman,Hertzel Gerstein,Sibylle Hess,Shun Fu Lee,Lars Ryden,Linda Mellbin

doi:10.1016/s0735-1097(19)32366-6

Abstract

The role of testosterone and sex hormone-binding globulin (SHBG) in female cardiovascular disease and dysglycemia is debated. The present objective was to investigate the prognostic impact of total (TT) and free testosterone (FT) and SHBG in women at high cardiovascular risk and dysglycemia.

Highlights

The importance of sex hormones in the development of cardiovascular disease in women has been debated
Whereas the focus has traditionally been on estrogen,[1] the importance of testosterone and its binding protein sex hormonebinding globulin (SHBG) has attracted recent attention.[2]
The present study investigates the prognostic impact of testosterone and SHBG on the development of cardiovascular outcomes in female participants in the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial[11] comprising a well-defined cohort of dysglycemic patients at high cardiovascular risk

Summary

Introduction

The importance of sex hormones in the development of cardiovascular disease in women has been debated. Whereas the focus has traditionally been on estrogen,[1] the importance of testosterone and its binding protein sex hormonebinding globulin (SHBG) has attracted recent attention.[2] Testosterone acts both as an androgen and as a precursor of estradiol and exerts important physiological effects on well-being, sexual function, bone metabolism and cardiometabolic health.[3] Studies in women of reproductive age and with polycystic ovarian syndrome (PCOS), a condition typically characterized by hyperandrogenism Testosterone levels) and hyperinsulinemia, have suggested an increased risk of developing cardiovascular risk factors the effects on cardiovascular mortality is unclear.[4,5] To what extent testosterone is related to prognosis in middle-aged and elderly women with dysglycemia remains to be clarified

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Discussion

Conclusion