Testing Toxicity and Antidote Effect of Selenium Nanoparticles with &amp;lt;i&amp;gt;Paramecium caudatum&amp;lt;/i&amp;gt;

Khandsuren Badgar,József Prokisch

doi:10.4236/ojas.2021.114036

Abstract

A simple method for assessment of the toxicity and antidote effect of selenium nanoparticles with Paramecium caudatum is presented. Light microscopy in combination with computerized video tracking is employed for the determination of the survival time of P. caudatum. Up to 800 mg/L, selenium nanoparticles are not acutely toxic. With respect to a potential antidote effect, the lethality of silver nanoparticles, silver nitrate, sodium hydrogen selenite, and sodium selenite to P. caudatum was decreased and survival time was extended upon pre-treatment with selenium nanoparticles. Taken together, these findings suggest that administration of selenium nanoparticles attenuates exposure to toxicants. Selenium nanoparticles could be a good functional additive for food management in animals.

Highlights

Protozoan cells are often used as bioindicators of chemical pollution and their toxicity in an aqueous environment [1]
The concentration of selenium nanoparticles higher than 800 mg/L was shown to exert no effects on locomotion and morphology of P. caudatum
These results indicated no morphological changes in P. caudatum

Summary

Introduction

Protozoan cells are often used as bioindicators of chemical pollution and their toxicity in an aqueous environment [1]. Paramecium caudatum is one of the widely used ciliate models as bioindicators for scientific research. Komala reported the acute toxicity test of P. caudatum is highly sensitive to investigate the direct toxicity of chemical compounds [2]. Paramecium simplifies the study of physiological processes and effects of water pollutants such as mineral oil, pesticides, metals, and others by monitoring locomotor behavior, morphol-. A sensitive measure of stress by water contamination [8] is locomotion, depending on the movement of the cilia mostly controlled by the action potential of the cell membrane [9] [10]. The antidote effect of selenium nanoparticles on P. caudatum is evaluated in a simple fashion

Methods

Results

Conclusion