Abstract
Interactions between the auditory and the motor systems are critical in music as well as in other domains, such as speech. The premotor cortex, specifically the dorsal premotor cortex (dPMC), seems to play a key role in auditory-motor integration, and in mapping the association between a sound and the movement used to produce it. In the present studies we tested the causal role of the dPMC in learning and applying auditory-motor associations using 1 Hz repetitive Transcranical Magnetic Stimulation (rTMS). In this paradigm, non-musicians learn a set of auditory-motor associations through melody training in two contexts: first when the sound to key-press mapping was in a conventional sequential order (low to high tones mapped onto keys from left to right), and then when it was in a novel scrambled order. Participant’s ability to match the four pitches to four computer keys was tested before and after the training. In both experiments, the group that received 1 Hz rTMS over the dPMC showed no significant improvement on the pitch-matching task following training, whereas the control group (who received rTMS to visual cortex) did. Moreover, in Experiment 2 where the pitch-key mapping was novel, rTMS over the dPMC also interfered with learning. These findings suggest that rTMS over dPMC disturbs the formation of auditory-motor associations, especially when the association is novel and must be learned rather explicitly. The present results contribute to a better understanding of the role of dPMC in auditory-motor integration, suggesting a critical role of dPMC in learning the link between an action and its associated sound.
Highlights
Auditory-motor integration is crucial for the learning and production of music and speech
The current results provide some of the first direct causal evidence in humans that dorsal premotor cortex (dPMC) is involved in the learning and expression of auditory-motor associations
Inhibitory 1 Hz repetitive Transcranical Magnetic Stimulation (rTMS) over dPMC impaired participants’ ability to learn the association between a pitch and a keypress in two independent samples, and this effect was greatest when they were required to learn an unconventional, novel association. These findings are consistent with the hypothesized role of the dPMC in encoding sensory-motor associations, when they are complex or abstract. It is consistent with findings of previous neuroimaging studies showing that the dPMC is part of a network of regions engaged during learning of auditory-motor associations in the context of music
Summary
Auditory-motor integration is crucial for the learning and production of music and speech. Based on work in both animals and humans, the network of brain regions engaged in linking sound and action is thought to involve the auditory dorsal stream, including the posterior auditory, inferior parietal and premotor cortices [1,2,3,4,5,6]. Hickok and Poeppel [6] proposed a dual–. Testing the Role of Dorsal Premotor Cortex in Auditory-Motor Association Learning Using TMS
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