Testing the Go/NoGo processing schema for children with caffeine

Abstract

Event Abstract Back to Event Testing the Go/NoGo processing schema for children with caffeine Robert J. Barry1* and Frances M. De Blasio1 1 University of Wollongong, School of Psychology, Australia Aims: We recently developed a processing schema to describe the cognitive stages in the equiprobable auditory Go/NoGo task. Based on the PCA-derived ERP components observed in young adults, this has been used in a range of studies, and gradually extended to older and younger groups. A separate schema was developed for children, and recently updated using improved methodology involving separate Go and NoGo PCAs. Here we test the appropriate segregation of components in the separate Go and NoGo processing streams using caffeine’s stimulant properties; processing-specific components in each stream should be amplified by caffeine. Methods: Twenty-four children, aged 8-12 years and light-moderate caffeine users, participated in two sessions 1 week apart. A single oral dose of caffeine (80 mg) was presented in a randomised double-blind placebo-controlled repeated-measures cross-over design. Each session included 4 blocks of 150 tones; half were 1000 Hz, half were 1500 Hz, presented in random order, with the target tone balanced over subjects/sessions. EEG was recorded at 512 Hz from 19 scalp sites. Artefact-free Go and NoGo trials were separately averaged to form ERPs (-100 to + 750 ms) for the Caffeine and Placebo sessions, and each dataset was subjected to temporal PCA using covariance input, with extraction and Varimax rotation of all components. Results: Components extracted in Caffeine and Placebo matched those expected from the updated Child Processing Schema. Caffeine enhanced the Go Processing Negativity (PN), N2c, and P3b components. In NoGo, the PN and N2b components were enhanced. These caffeine amplifications match expectations of PN marking the end of stimulus categorisation, and the subsequent separate Go (N2c, P3b) and NoGo (N2b) processing streams. Conclusions: The amplifying/arousal properties of caffeine have confirmed the appropriateness of the major elements in our Processing Schema for children in this task. Keywords: Children, Caffeine, ERPs, Go NoGo task, Temporal PCA, Processing Schema Conference: ASP2017: 27th Annual Meeting for the Australasian Society for Psychophysiology, Parramatta, Australia, 29 Nov - 1 Dec, 2017. Presentation Type: Oral Presentation Topic: Abstract (General) Citation: Barry RJ and De Blasio FM (2019). Testing the Go/NoGo processing schema for children with caffeine. Conference Abstract: ASP2017: 27th Annual Meeting for the Australasian Society for Psychophysiology. doi: 10.3389/conf.fnhum.2017.224.00039 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 28 Sep 2017; Published Online: 25 Jan 2019. * Correspondence: Prof. Robert J Barry, University of Wollongong, School of Psychology, Wollongong, NSW, 2522, Australia, rbarry@uow.edu.au Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Robert J Barry Frances M De Blasio Google Robert J Barry Frances M De Blasio Google Scholar Robert J Barry Frances M De Blasio PubMed Robert J Barry Frances M De Blasio Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.