Abstract
Aim. To test the new selenium containing metal complex (Zn2+) compounds by acute hypoxia-hypercapnia method in experiments on mice for antihypoxic effect finding. Methods. The screening of antihypoxants in experiments on mice placed in acute hypoxia-hypercapnia condition (AH + H) among 11 new metal complex selenium containing compounds have been performed. Condition of AH + H in animals was formed by their placing in hermetic glass boxes with 0.25 L free volume. Each substance has been used once by intraperitoneal introduction 60 min. before mice placing in AH + H area in doses 10, 25, and 50 mg/kg. The “life span” parameter was used as a criterion of antihypoxic activity. At the definite steps of investigation all animals where undergone to rectal temperature measuring. Results. The antihypoxic effect was shown by 4 compounds among 11 (πQ2719, πQ2720, πQ2721, πQ2882). The greatest result in life span was found in substance πQ2721. In this case the right positive interaction between doses of substances and results was marked - doses 10, 25 and 50 mg/kg provide life span enlargements to 25.1, 81.7 (р < 0.05), and 186.1% (р < 0.005) in comparison with control groups correspondently. The efficiency of etalon substance πQ1983 was near to that of πQ2721 but in dose 50 mg/kg it becomes weaker in activity than new compound. Conclusion. The test resultant of 11 new metal complex (Zn2+) substance with selenium in structure of ligand in use of acute hypoxia-hypercapnia method shows the πQ2721 as an antihypoxant that was confirmed by significant mice life span enlargement after doses 25 and 50 mg/kg during its action that according with dose-dependent rectal temperature decrease. (For citation: Yevseyev AV, Surmenev DV, Parfenov EA, et al. Testing of new selenium containing metal complex compounds by acute hypoxia-hypercapnia method. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(4):46-52. doi: 10.17816/RCF15446-52).
Highlights
Резюме Цель — тестирование новых селенсодержащих металлокомплексных (Zn2+) соединений на модели острой гипоксии с гиперкапнией в опытах на мышах на предмет обнаружения антигипоксического эффекта
The screening of antihypoxants in experiments on mice placed in acute hypoxia-hypercapnia condition (AH + H) among 11 new metal complex selenium containing compounds have been performed
Condition of AH + H in animals was formed by their placing in hermetic glass boxes with 0.25 L free volume
Summary
Опыты выполнены на 266 мышах-самцах линии CBF1 массой 20–30 г. Для тестирования веществ была использована популярная в подобных экспериментах модель ОГ + Гк [7]. Состояние гипоксии у животных формировали путем помещения в герметизированные стеклянные емкости со свободным объемом 0,25 л. В ходе наблюдения в качестве критерия антигипоксического действия использовали показатель «продолжительность жизни». Гибель мышей констатировали сразу же после возникновения стойкого апноэ. За 60 мин до начала опыта и перед помещением в условия ОГ + Гк у животных измеряли ректальную температуру с помощью электротермометра ТПЭМ‐1. Всего было исследовано 11 ранее не изучавшихся селенсодержащих металлокомплексных соединений Вещества растворяли в физиологическом растворе NaCl (0,3 мл) и вводили внутрибрюшинно (в/б) однократно до помещения. Общая характеристика исследованных селенсодержащих комплексных соединений цинка
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