Abstract
SummaryIn this review, different test systems with fish according to the German Chemicals and Plant Protection Acts are introduced and evaluated. On the basis of a critical consideration of these test systems, the following test concept with zebrafish (Danio rerio) is proposed: Base level:For ethical reasons,the conventional routine actute toxicity test with juvenile or adult fish should be replaced by a 48 h embryo test with zebrafish. Level 1: At level 1, the early life-stage test (OECD guideline 210) deserves priority over the prolonged fish test according to OECD guideline 204. Level 2: Only a complete life-cycle test fulfills the requirements of a chronic toxicity test. It can, therefore, not be substituted by an early life-stage test. Since extrapolation from acute-chronic ratio (ACR) data is not possible as well, there is no alternative to a complete life-cycle test.
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