Abstract
In this issue of The Journal, Shah et al contribute an observational study of hospitalized infants less than 2 months of age whose cerebrospinal fluid is examined as part of diagnostic evaluation. Their hypothesis was simple—the decision to test cerebrospinal fluid for herpes simplex virus (HSV) by polymerase chain reaction (PCR) test is associated with prolongation of hospitalization. In multivariate analysis, the answer was simple—ordering HSV PCR test was associated with increase in length of stay of 28% for infants <28 days of age and 39% for infants 29-56 days of age.
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