Abstract
Gastric cancer (GC) is a major source of cancer-related morbidity and mortality worldwide.1 Up to 10% of cases demonstrate familial aggregation, although whether this is due to genetic factors, shared environment with exposures to toxins, such as Helicobacter pylori infection or tobacco smoke, or a combination of the two is unclear.2 Family history of a first-degree relative with GC increases lifetime risk by 2.5-fold, as does H pylori infection.3,4 A recent randomized controlled trial demonstrated a significant reduction in GC incidence in patients undergoing regular endoscopic surveillance, who had a first-degree relative with GC, were treated for H pylori infection.
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