Abstract
Enzyme reactions in the camel testis involved in androgen synthesis were studied to determine the factors which account for the low testosterone production during the nonmating season (NMS). Testes excised during the NMS were found to have a relatively high activity of the eβ-hydroxysteroid dehydrogenase systems of pregnenolone, 17α-hydroxypregnenolone, and dehydroepiandrosterone, but the 4-ene-17α-hydroxylase and 4-ene-17,20-lyase systems were apparently less active than the 5-ene-17α-hydroxylase and 5-ene-17,20-lyase. On the other hand, testes excised during the mating season (MS) were found to have a relatively high activity of 4-ene-17α-hydroxylase, 4-ene-lyase, and 17β-hydroxysteroid oxidoreductase. The 19-hydroxylation and aromatizing activities for testosterone and androstenedione were not detected in testes excised in either season. It is proposed that during the NMS the predominant route of testosterone biosynthesis is pregnenolone → 17α-hydroxypregnenolone → dehydroepiandrosterone → androst-5-en-3β, 17β-diol → testosterone.
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