Abstract
The effects of two doses (250 and 1000 rads) of local gamma irradiation on testes of adult rats are reported after 1, 2, 4 and 16 weeks. There was a significant increase in DNA content per gm testes at 1 week; a gradual decrease at 2 and 4 week intervals was followed by a trend towards recovery at 16 weeks post-irradiation. The rate of synthesis of both DNA and RNA as studied by the incorporation of (3H) - thymidine and (3H) -uridine, showed similar results. Total protein content per gm testis declined with both doses and at all post-irradiation intervals. Histological observation showed loss of spermatogenic cells suggestive of DNA loss.
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