Abstract
Fifty two patients with unilateral varicocele, aged 8 to 19 years were studied and grouped in 5 Grades of Puberty. Basal plasma testosterone (T), LH and FSH before and after GnRH administration were measured in all patients. Testicular histology was studied in 14.Microscopical examination revealed normal development of germinal epithelium according to the grade of puberty. These results demonstrated that patients with varicocele have a tendency to increase LH and T secretion probably secondary to a metabolic disturbance induced by a higher intratesticular temperature detected even before puberty. FSH and germinal function remained normal, suggesting that small tes-ticular volume could be due mainly to the abnormal metabolic interstitial process than to a seminiferous tubule damage.
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