Testicular damage after chronic exposure to carbendazim in male goats

Abstract

The present investigation was aimed to determine the effect of chronic exposure of carbendazim on cellular changes in testes of male goats. The goats were randomly divided into two groups, control and treatment (N = 7 each). The treatment group was exposed to carbendazim at the dose rate of 50 mg kg−1 body weight per day orally, once daily for 180 consecutive days. Testes were removed from control and experimental animals surgically on the 90th, 120th, and 180th day. On the 180th day of the treatment, a maximum number of seminiferous tubules became atrophic, and vacuolization of germinal epithelium, and sloughing of the germinal epithelium and sertoli cells was more marked as compared to days 90 and 120. Some of the seminiferous tubules were devoid of germinal cells. These pathological findings were supported by ultrathin and electron microscopic examination. On the basis of the present investigation it could be concluded that chronic exposure of carbendazim in male goats did not allow proper maturation of testis.