Abstract
This study was carried out to investigate the ameliorative effect of L-carnitine on monosodium glutamate (MSG)-induced testicular toxicity in male mice. Sixty adult male mice were randomized into 6 groups (n = 10). In addition, to the control male mice group (Gp1) that orally administered distilled water, Gp2 mice received 150 mg/kg/day L-carnitine for 35 days. Monosodium glutamate (MSG) was orally administered to male mice at doses of 0.3 and 0.6 mg/g body weight individually (Gp3 & Gp4) and in combination with 150 mg/kg body weight of L-carnitine for 35 days (Gp5 & Gp6). The morphometric parameters, histopathological findings and immunohistochemical studies for PCNA, Ki-67 and Claudin-1 of the testis tissue demonstrated that L-carnitineattenuated and ameliorated the alterations in testicular tissues caused by MSG exposure. Conclusions: The findings of the present study indicated that treatment of male mice with L-carnitine banned MSG-induced testicular toxicity by improving testicular structure status.
Highlights
Infertility is one of the worldwide and most important global medical concerns affecting millions of couples (Ross et al, 2010; Eslamian et al, 2012).Declines occurred in the semen quality maybe contribute to environmental pollutants, occupational exposures, or lifestyle (Homan et al, 2007)
The findings of the present study indicated that treatment of male mice with L-carnitine banned Monosodium glutamate (MSG)-induced testicular toxicity by improving testicular structure status
All these symptoms disappeared by the time. These symptoms disappeared among mice treated with MSG and co-administered with L-carnitine
Summary
Infertility is one of the worldwide and most important global medical concerns affecting millions of couples (Ross et al, 2010; Eslamian et al, 2012). Declines occurred in the semen quality maybe contribute to environmental pollutants, occupational exposures, or lifestyle (Homan et al, 2007). (2015) reported food additives as an important food component that affects semen quality. The food additives have some devastating effects on the consumer so, must be added in concentrations, regulated quantities, and should be within the acceptable daily intakes (Kunkel and Barbara, 2004). Monosodium glutamate (MSG) is commonly used in processed food to preserve flavor and enhance taste or as flavouring agents or food additives (Rosa et al, 2015). Many drug control and food agencies have certified MSG to be safe for human consumption without any specified dosage (Eweka and Om’Iniabohs, 2008)
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