Test the effectiveness of clove leaf ethanol extract on wound healing in rats

Abstract

Clove leaves (Syzygium aromaticum (L.) Merr. & Perry) contain alkaloid compounds, flavonoids, tannins and essential oils that play a role in wound healing. This study used 20 male mice as samples divided into 4 treatment groups, namely group 1 (negative control group), group 2 (positive control group), group 3 (15% clove leaf extract ointment), and group 4 (leaf extract ointment). clove concentration 20%). All mice were injured 2 cm long. The results showed that there was a difference between the control and the clove leaf extract ointment at concentrations of 15% and 20%. In the Wilcoxon test the results showed a p value <0.05 where there was a treatment group. And for the Mann Whitney test the results showed that there were differences between the control group and the clove extract ointment. The p value for the three comparisons was only negative control with clove leaf extract ointment with a concentration of 15% and a concentration of 20% which was smaller than 0.05. So the hypothesis Ho is rejected, there is a difference between the negative control with clove leaf extract ointment with a concentration of 15% and 20%.