Test Of Analgesic And Antiinflamation Effect Of Ethanol 70% Extract Red Gedi Leaves (Abelmoschus manihot (L.) Medik.) From Palu On White Rat (Rattus novergicus)

Abstract

Test of analgesic and anti-inflammatory effect of ethanol extract 70% leaf Red Gedi (Abelmoschus manihot (L.) Medik) against male rat (Rattus norvegicus). The purpose of this study was to determine the general purpose of this study was to determine the analgesic and antiinflammatory effect of ethanol extract of 70% leaf Red gedi (Abelmoschus manihot (L.) Medik) Against male rats (Rattus novergicus). This research is an experimental research with approach of pre and post test control group design. The sample was divided into 5 groups, ie normal group, negative control, positive control, and group extract. In the extract group, 3 doses of different extracts were extract dose 150 mg/kg BW, 300 mg/kg BW, and 450 mg/kg BW. Determination of analgesic with Writhing test method induced with acetic acid 1% while anti-inflammatory with the formation of artificial edema with 1% caragen inducer. The analgesic and anti-inflammatory effect was obtained on ethanol extract of 70% leaf red gedi (Abelmoschus manihot (L.) Medik) at doses of 150 mg/kg BW, 300 mg/kg BW, and 450 mg/kg BW characterized by the number of stretching and inflammation On different legs with the control group. The result of statistical analysis using SPSS (Statistical Product and Service Solution) method showed that analgesic and anti-inflammatory effect was shown by ethanol extract 70% of leaf Red gedi (Abelmoschus manihot (L.) Medik). Doses of 150 mg/kg BW, 300 mg/kg BW, and 450 mg/kg BW were not significantly different from mefenamic acid and diclofenac sodium.