Test and analysis for the polymorphism rs4934 of the serine protease inhibitor member 3 of clade a gene in intracranial aneurysmsin the Chinese poputation

Abstract

Objective Serine protease inhibitor member 3 of clade A (SERPINA3) gene on chromosome 14o32. 1 has been showed to be associated with intracranial aneurysms in a Polish population. In this study, the purpose was to test and analyze the polymorphism of the SERPINA3 in intracranial aneurysms in Chinese Hah nationality. Method To compare the genotype frequency and A allele frequency of rs4934polymorphism of the SERPINA3 in 275 patients with intracranial aneurysms and 361 controls by polymerase chain reaction and Taqman MGB probe analysis. Results The GA + AA genotype frequency of rs4934 polymorphism of SERPINA3 of aneurysm group (85. 1%)was no much higher than that of control group (81.44%) (χ2 = 1.475,P = 0.224). The A allele frequency ofaneurysm group (58.55%) was also no higher than the control group (59. 14%)(χ2 = 1.445, P = 0. 229). Adjustment for age, sex using logistic regression did not change the results (χ2 = 1. 499, P = 0. 221 ). Conclusions There is no significant difference of the rs4934 polymorphism of SERPINA3 between intracranial aneurysms and controls among individuals of Chinese Han nationality. Key words: Intracranial aneurysm; SERPINA3; Single nucleotide polymorphism