Tessellation-based modeling and flow simulation of pulmonary acinus with alveolar pore

Abstract

PurposeThis study aims to perform flow simulations inside the acinus with fine alveolar pores (Kohn pores) using hexagonal cells and bottom-up geometric modeling, which enabled the elimination of invalid voids using previous top-bottom methods and spherical or circular cells.Design/methodology/approachRegular hexagonal cells were used to construct alveoli with no gaps via tessellation. Some hexagonal cells were fused to eliminate the inner boundaries to represent the structure of the bronchial tree. For the remaining hexagonal cells, the side lengths of the shared walls were adjusted to construct alveolar pores. Periodic moving boundaries with the same phase were set for all walls to describe synchronous contraction and expansion of the bronchi and alveoli.FindingsMore realistic flow characteristics in the distal lung were obtained. The effects of pore size and the mechanism of auxiliary ventilation of alveolar pores were revealed.Originality/valueTo the best of the authors’ knowledge, this is the first numerical simulation study on the function of multiple alveolar pores at the level of pulmonary acini, which will be helpful for simulating the dynamic process of cough and sputum excretion in the future.