Abstract
Although other antibiotics have been introduced since penicillin became generally available, it still remains the most widely used of these agents. This might be expected, since it is unsurpassed in the treatment of many bacterial infections, especially those caused by pyogenic cocci. On the other hand, its scope of usefulness is not all-inclusive. Mixed infections respond poorly to penicillin alone. Many strains of staphylococci are penicillin-resistant.1Some patients cannot tolerate penicillin because of hypersensitivity, a problem which perhaps may be solved by the introduction of penicillin O, although this new product has not yet been fully investigated.2Finally, although oral administration would be preferable in the use of antibiotics, the full potentialities of penicillin by this route remain to be established. The need for an alternative antibiotic agent is therefore clear, and at the present time three possibilities present themselves: (1) chloramphenicol3and (2) aureomycin,4which
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