Abstract
Abstract Aged or senescent cells develop a complex senescence-associated secretory phenotype (SASP). However, the mechanisms underlying the induction of the SASP are unclear. Telomeres are critical for genome stability and aging. Telomeres are transcribed into long non-coding telomeric repeat-containing RNA (TERRA) molecules. We demonstrate that TERRA and inflammatory cytokines were significantly elevated during senescence. Over expression of TERRA significantly upregulated IL-6 and IL-8, but IL-6 and IL-8 did not modulate TERRA expression. The results show that TERRA expression is related to senescence and increases production of SASP. Our findings expand the biological function of TERRA in senscence-assosciated inflammatory responses.
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