Abstract
Agelasines, asmarines and related compounds are natural products with a hybrid terpene-purine structure isolated from numerous genera of sponges (Agela sp., Raspailia sp.). Some agelasine analogs and related structures have displayed high general toxicity towards protozoa, and have exhibited broad-spectrum antimicrobial activity against a variety of species, including Mycobacterium tuberculosis, and also an important cytotoxic activity against several cancer cell lines, including multidrug-resistant ones. Of particular interest in this context are the asmarines (tetrahydro[1,4]diazepino[1,2,3-g,h]purines), which have shown potent antiproliferative activity against several types of human cancer cell lines. This review summarizes the sources of isolation, chemistry and bioactivity of marine alkylpurines and their bioactive derivatives.
Highlights
Natural products have been a rich source of agents valued in medicine and are the most productive source of developmental drugs [1,2,3,4,5,6,7,8,9,10,11,12]
Recent research focused on marine natural products has uncovered a useful way to obtain a potentially rich source of drug candidates [28,29,30,31,32,33], where alkaloids have been found to be more effective in several therapeutic fields
This review presents a comprehensive review of the literature published about several aspects of alkylpurine metabolites from marine sponges, including the structure, isolation, biological activity and chemistry of marine metabolites with a terpene-purine structure, as well as their ability to act as antifouling agents
Summary
Natural products have been a rich source of agents valued in medicine and are the most productive source of developmental drugs [1,2,3,4,5,6,7,8,9,10,11,12]. Agelasines, asmarines and related compounds are characteristic marine metabolites frequently isolated from sponge genera Such compounds have attracted the attention of researchers because of their potent biological activities, which have been reported to include antimicrobial [34,35], antiproliferative [36], antileukemic [37], cytotoxic [34,38], antiprotozoal [39,40] and antituberculosis properties [41] and inhibitory effects on the enzymatic reactions of Na+,K+-ATPase [42].
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