Abstract
A thorough investigation of Cacalia tangutica (Franch.) Hand-Mazz afforded two new epimeric eremophilane sesquiterpenoids, 7β- H-3α-angeloyloxy-9-ene-11,12-epoxy-8-oxoeremophilane (1) and 7α-H-3α-angeloyloxy-9-ene-11,12-epoxy-8-oxoeremophilane (2), as well as four known sesquiterpenes, petasol (3), oplopanone (4), 4,5-epoxy-β-caryophyllene (5), 4(15)-eudesmene-1β,6α-diol (6), and three known monoterpenes, 1β,2α-dihydroxy-p-menth-5-ene (7), 5α-hydroxy-2-oxo-p-menth-6(1)-ene (8), 5β-hydroxy-2-oxo-p-menth-6(1)-ene (9), and two known triterpenes, maniladiol 3-O-palmitate (10), taraxasteryl palmitate (11). The new compounds were characterized by means of spectroscopic methods including 1D, 2D NMR and HRESIMS, and the known ones were established on the basis of comparing their NMR data with those of the corresponding compounds in the literature. In addition, cytotoxicity against selected cancer cells (HL-60, HO-8910 and A-549) of compounds 1-4, 6, 7,10 were measured in vitro.
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