Ternary complexes of palladium (II) with levamisole and l-amino acids

Abstract

The complexes of general formula [(LMS) 2Pd(amino acid)]Cl with LMS = levamisole, and amino acid = l-alanine, l-phenylglycine, l-phenylalanine, l-valine, l-methionine, and l-proline, were synthesized by the interaction of [(LMS) 2PdCl 2] with the sodium salts of l-amino acids. The newly synthesized complexes are characterized by elemental analysis, conductivity, magnetic susceptibility, optical rotation measurements, and UV-Vis, IR and 13C NMR spectral data. Levamisole is coordinated to palladium via the N-7 nitrogen and the amino acids through the amino nitrogen and carboxylate oxygen, except for l-methionine which binds the metal via nitrogen and sulfur atoms. Optically active [(LMS) 2Pd(amino acid)]Cl complexes are obtained when l-amino acids or d,l-amino acids are used for the synthesis of these complexes. l-Methionine and l-proline complexes induce new cell forms in Baker's yeast ( Saccharomyces cerevisiae) cells.