Termination of acquired immunological tolerance in mice with antigen aagregates.

Abstract

SummaryNeonatal inoculation of 10 mg of human gamma globulin rendered HS mice immunologically unresponsive to it for as long as inoculation was repeated. Inoculation of heat aggregated HGG was followed by a breakdown of the tolerant state. When tolerant mice were treated with mild heated gamma globulin, tolerance was not terminated but prolonged. Animals that terminated tolerance developed antibodies that reacted specifically with the Fc piece of IgG.The technical assistance of Mr. Ken Adkins and Mr. Glenn Lawrence is gratefully acknowledged.