Terminating the spiral wave and spatiotemporal chaos in cardiac tissue using the low-pass filtering scheme

Abstract

To cause the sodium ion activation gate of cardiomyocyte delay to open, the ability of excitation delay should be given to the medium. The time of excitation delay of the medium increases as the control voltage and frequency of stimulation increase. When the control voltage exceeds a threshold value, the medium with excitation delay has the property of low-pass filtering: low-frequency waves can continuously pass through the medium, whereas the high-frequency wave does not pass consecutively. In this paper, the effect of excitation delay of the medium on spiral waves and spatiotemporal chaos is investigated by using Luo-Rudy phase I model. Numerical simulation results show that when the control voltage exceeds the threshold value, the excitation delay of the medium can effectively eliminate the spiral wave and spatiotemporal chaos. When the control voltage gradually increases from a small value, at a small maximal conductance of calcium channel, the excitation delay could reduce the excitability of the medium, making the amplitude of the spiral wave meander increase until conduction failure results in the disappearance of the spiral wave. Under a large maximal conductance of calcium channel, the excitation delay can reduce the unstability of the spiral wave so that spatiotemporal chaos evolve into meandering spiral waves when the control voltage is large enough. The phenomenon that the spiral wave with a large meandering motion of its tip moves out of the system is observed when the control voltage is properly chosen. Further increase of the control voltage leads to the disappearance of spatiotemporal chaos.