Abstract
Objective: The aim of this study was to identify the potential of Terminalia chebula as a protective and therapeutic agent against Alzheimer’s disease. Methods: The learning and memory enhancing activity of Terminalia chebula fruit extracts were investigated in rats by using the ethanol- induced cognitive impairment and diazepam induced amnesia and its effects on learning and memory were examined by using Morris water maze (MWM) test. Results: All the groups showed significantly (P value is<0.01 and <0.05) decrease transfer latency at all periods as compared to ethanol and diazepam inducing group. Therefore Fruit extracts of Terminalia chebula exhibited significant learning and memory activity in Alzheimer’s disease. Conclusion: The present study suggests Terminalia chebula that modulate the oxidative stress and be involved in the protective effect against oxidative damage and neurodegenerative diseases in rat.
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