Abstract
Objective: The objective of this research work was to prepare a transdermal matrix formulation containing different polymer components for topical delivery.
 Methods: Terminalia arjuna bark extract loaded transdermal patches were prepared using solvent casting technique with different amount of chitosan and Eudragit RL 100 batches were prepared according to 32 factorial designs.
 Results: The transdermal patches prepared were evaluated for different physicochemical properties, determination of drug content, in vitro diffusion study, ex vivo study, skin irritation study, and stability study. Infrared studies indicate the absence of chemical interaction or any changes in the chemical composition of extract during the preparation of transdermal patch. In vitro diffusion study and ex vivo diffusion study of optimized batch S3 showed drug releases to 74.56–69.12%, respectively, up to 12 h. Skin irritation study indicates that the extract and excipients used in the patch do not show any irritating effect on the skin. All the prepared transdermal matrix formulations were found to be stable on storage.
 Conclusion: It can be concluded that prepared matrix formulation containing different polymer components can be used for transdermal delivery for the treatment of chronic ailments such as cardiovascular disorder.
Highlights
Transdermal matrix system (TMS) encompasses the uniform dispersion of drug in the polymeric matrix that has a hydrophilic or hydrophobic identity
TMS has been showing an increased interest than other delivery methods, one of which is to avoid the metabolism of the first pass effect on the liver and able to deliver the drug in a controlled manner directly to the blood vessels
The Fourier transform infrared (FTIR) spectrum of pure extract and formulation is depicted in Figs. 1 and 2, respectively
Summary
Transdermal matrix system (TMS) encompasses the uniform dispersion of drug in the polymeric matrix that has a hydrophilic or hydrophobic identity. TMS has been showing an increased interest than other delivery methods, one of which is to avoid the metabolism of the first pass effect on the liver and able to deliver the drug in a controlled manner directly to the blood vessels. Transdermal administration can give local therapeutic effect as well as a systemic effect [1,2,3]. Terminalia arjuna is a deciduous and evergreen tree, which has been used in heart failure, ischemia, cardiomyopathy, atherosclerosis, myocardium necrosis, blood diseases, anemia, venereal, and viral disease. It is used in the treatment of several ailments and showed hypocholesterolemic, antibacterial, antimicrobial, antitumoral, antiallergic, antifeedant, antifertility, and anti-HIV activities. Phytoconstituents of T. arjuna have been well reported to exert antioxidant, anti-inflammatory, lipid-lowering effect, and cardiotonic effect [9]
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