Abstract
A large number of interesting Co (II) complexes with macrocyclicligands have been synthesized and the recognition of its complexes as important bioactive compounds in vitro and in vivo has aroused growing interest in these agents as potential drugs for therapeutic use in various diseases. Numerous available information on their bioinorganic properties and mode of action in several biological systems, combined with the new possibilities imposed by the development of medical chemistry, opens space for the development of a new generation of highly active drugs with minimized side effects which could add significantly to the current clinical research and practice. In this paper we attempt to present some properties of the earlier isolated the first Co(II)tpmc complex for which crystal structure confirmed chair conformation of macrocycle. Complex with formula (Co2(Cl)2tpmc)(BF4)2 (tpmc = N,N`,N``,N```tetrakis(2-pyridylmethyl)-1,4,8,11 - tetraazacyclotetradecane), was studied on thermal behaviour and biological activity. TG-DTA analysis indicates that complex decomposition in a single step in the range of 365 -435 °C. Investigated cytotoxic activity against two human cancer cell lines: HeLa (human cervix adenocarcinoma) and K562 (human myelogenous leukaemia). Complex was also preliminary assayed in vitro toward bacteria, fungi and mould together with the starting material for the synthesis (ligands, simple salts and solvents) as test substances. Investigated complex showed a moderate activity against strains of bacteria and were inactive against the tested fungi and mould. Minimal inhibitory concentration suppressing the visible growth of bacteria was determined. Biological investigations show the complex has significant cytotoxic potential.
Highlights
Macrocyclic ligands with metal ions usually create construction of stable complexes of different structures, catalytic, redox, etc. characteristics
We described the crystal structure of the complex [Co2(Cl)2tpmc](BF4)2 [10]
Each metal is exo coordinated by two rings (NCH2CH2N) and two pendant-N atoms in the complex cation [Co2(Cl)2tpmc]2+ (Figure 2)
Summary
Macrocyclic ligands with metal ions usually create construction of stable complexes of different structures, catalytic, redox, etc. characteristics. Macrocyclic ligands with metal ions usually create construction of stable complexes of different structures, catalytic, redox, etc. This complexes have important implications for a range of chemical and biochemical applications [1]. One of the attractive macrocyclic ligands is the tpmc, a fully N-substituted cyclam with pendant 2pyridylmethyl groups.
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