Teriparatid [paratiroid hormon (1-34)] ve diş hekimliği

Abstract

Teriparatide is a new synthetic parathyroid hormone recently used with a purpose to improve the thickness and the quality of bone. Parathyroid hormone regulates the metabolism of calcium and phosphate and is responsible for bone formation. Teriparatide is a new antiosteoporosis drug and is known to prevent bone resorption in cases where mineral density is low or the quality of bone is inferior. Unlike other antiresorptive agents it possesses an anabolic effect on bone. In its mechanism of action, when bone resorption starts with osteoclast stimulation, osteoblasts are stimulated at the same time, resulting in the aforementioned anabolic effect. This effect has tempted researches to use this agent in cases of biphosphonate related osteonecrosis and periodontal bone defects. Research reveals no serious clinical side effects associated with this agent; however, a risk of osteosarcoma due to its anabolic effect on bone should be considered. Yet, no case of osteosarcoma related to the teriparatide use has been reported so far. In the literature, there exists only few case reports that has used teriparatide. Prospective randomized studies are needed to evaluate the long-term effectiveness of this drug.