Abstract
Metiapine, a dibenzothiazepine tranquilizer, was tested for teratogenic effects in rats and rabbits and for its effect on reproduction and postnatal development in rats. Doses of 3 and 10 mg/kg/day during the period of organogenesis were without effect on fetal development. Doses of 30 mg/kg/day caused increased fetal deaths and all 3 doses caused poor reproductive efficiency in rats by inhibiting the estrous cycle. Perinatal and postnatal studies conducted in rats at these same doses revealed poor survival and growth rates in the newborn, which were attributed to lack of maternal care. With the exception of fetal wastage, these effects were attributed to the psychotropic activity of metiapine and its secondary effects on food consumption, maternal behavior and endocrine function.
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