Teratologic evaluation of dermally applied zinc pyrithione on swine

Abstract

A teratologic study in Yorkshire pigs was performed by applying zinc pyrithione (30, 100, or 400 mg/kg prepared as a 50% ( w v ) suspension in Aquaphor cream) for 8 hr per day on the clipped dorsal surface from Days 8 through 32 of gestation. The design of the experiment also included a naive and a vehicle-treated control group. Piglets obtained by Caesarian section on gestation Day 100 were examined for external, soft tissue, and skeletal (X-ray) abnormalities. The number of implantation and resorption sites and viable fetuses among the test groups was not significantly different than the control groups. No evidence of any teratogenic or embryotoxic effect was observed in the fetuses from dams treated with zinc pyrithione.