Abstract
The teratogenic potential of a mixture of polybrominated biphenyls (PBB) was investigated. Pregnant Wistar albino rats were given single doses of PBB in seasame oil by gavage on one day of pregnancy, from day 6 through 14 (sperm day = 0). The dose ranged from 40 to 800 mg/kg maternal body weight. At autopsy (day 20) fetuses were recovered and subsequently examined for skeletal and soft-tissue abnormalities. Resorptions followed treatment at all days. No skeletal malformations were seen at any dose level. The majority of soft tissue defects were found following 800 mg/kg PBB at day 11, 12, or 13. Only two malformations were produced, cleft palate and diaphragmatic hernia. It is concluded that a single high dose of PBB can be embryolethal and teratogenic to the rat embryo.
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