Abstract
The teratogenic risk after first trimester exposure to carbamazepine was determined from 210 pregnancies followed prospectively at the Israeli Teratogen Information Service, and Laboratory of Teratology, Hebrew University, Hadassah Medical School, and Ministry of Health, Jerusalem, Israel.
Highlights
A twofold increase in the rate of major congenital anomalies occurred in the carbamazepine compared to the general control group (12/160 vs 18/560; relative risk 2.24)
Poor seizure control may not be associated with an increased risk of psychiatric diagnoses and symptoms, but the high rate of refractory epilepsy and effect of antiepileptic drugs on behavior limit the significance of this finding
Poor seizure control was significantly correlated with mean total and Internalizing child behavior checklist (CBCL) scores but not with K-SADS diagnoses or symptoms
Summary
A twofold increase in the rate of major congenital anomalies occurred in the carbamazepine compared to the general control group (12/160 vs 18/560; relative risk 2.24).
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