Abstract
Single doses of 25–70 mg/kg of lead nitrate were administered iv to pregnant rats on Days 8–17 of gestation (Day 1 = sperm found). Malformations were produced with lead when administered on Day 9 of gestation, producing a urorectocaudal syndrome of malformations. Lead nitrate was increasingly embryo- and fetotoxic when administered on later days of gestation (Days 10–15) but not teratogenic. Hydrocephalus and hemorrhage of the central nervous system were produced on Day 16 of gestation. On Day 16 and therafter, fetal toxicity (resorptions) sharply declined. Postnatal survival of newborn exposed in utero to lead on Day 9 of gestation was very poor. Significant quantities of lead were transferred into the fetus; however, the placenta appeared to greatly limit the passage of lead since large maternal-fetal concentration gradients existed.
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