Abstract
Three consecutive days injection of pregnant ddO female mice with actinomycin‐D (ACT‐D) saline solution was carried out on a variable time schedule, from the 1st to 15th day of gestation. Fetuses were examined on the 18th day of gestation, revealing the following results.The sensitive period for malformation is from the 4th to 8th day of gestation with incidences of 31.7%‐3.3% in 2.5 μg ACT, and of 3.3%‐1.6% in 1.25 μg ACT.Malformations induced by ACT are celosomia, anophthalmia, fissure of the mandibula, open eyelids, small external ear, etc. Celosomia is the most outstanding feature with 22 of the 23 malformed fetuses (95.7%) showing this condition.Malformed fetuses are smaller in average body weight than the normal ones.Malformations of the bones observed in 260 fetuses consist of fissure of the jaw I, sphenoideal fissure I, abnormal curves of the ribs 4, and separation of vertebral arch of the first cervical vertebra 2. These changes are not related to the period of ACT treatment.Over‐all malformations of the bones are frequently seen on the 5th‐7th day and the 12th–15th day of gestation. ACTA PATH. JAP. 18: 267–286, 1968.
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