Teratogenic Effect of Ace Inhibitor (Lisinopril) and Chrysanthemum Indicum(Guldaudi) on Head and Face Region of Mice Fetuses

Abstract

Lisinopril an ACE inhibitor when administered to pregnant mice was found to be teratogenic. Chrysanthemum indicum extract was also administered to pregnant mice and compared with the teratogenic effect with those produced by lisinopril. Thirteen pregnantfemale mice were administered lisinopril orally in the dose of 2mg/100g and Guldaudi extract 50mg/100g body weight of mice. Lisinopril and Guldaudi were administered to pregnant mice daily from day zero of pregnancy. On day 18 mother mice was sacrificed and pups were collected. These, showed significant stunting in size (p<0.001) in both lisinopril and guldaudi groups. Exencephaly was found in 26.08% in lisinopril group; however hypoplasia of skull was present in Guldaudi group. Resorption (5%) was noticed only in Guldaudi group. The lisinopril in dose of 2mg/100g body weight tried was found to be teratogenic and dose of Guldaudi extract in the dose of 50mg/100g was also found teratogenic with less severity as compared to 2 mg dose of lisinopril. Oligohydramnios and hypoxia following lisinopril and Guldaudi administration was attributed to be the cause of these malformations.