Abstract
AbstractPregnant mice were injected ip with 0.25‐0.5 ml of either an antimouse‐, antirat‐, or antichicken kidney antiserum or a nonimmunized rabbit serum on various days of gestation, but principally days 7‐9. Both antirat‐ and antimouse‐kidney antisera crossreacted with mouse kidney but antichicken kidney antiserum did not. Both antimouse‐ and antirat‐kidney antisera were embryolethal and teratogenic in mice. Both antisera were localized by immuno fluorescence with goat antirabbit gamma globulins in the glomerular basement membrane of maternal kidneys and in Reichert's membrane and yolk‐sac endoderm of embryos. Antichicken‐kidney antiserum was not embryolethal or teratogenic in mice and the antiserum was not fixed in the maternal kidneys or embryonic membranes. The teratogenic agent(s) in rat and mouse nephrotoxic antisera, therefore, seems to be antibodies to class specific kidney antigens.
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