Abstract
Herpes simplex viruses (HSV) present one of the most frequent groups of viruses in the human population. Herpes simplex infections manifest through varying symptoms and lesions of the orofacial or genital tract. The peak of viral titers occurs within the first 24 h in both genital herpes and herpes labialis infections. Due to the rapid viral replication and subsequent progression of lesions in both Herpes labialis (HL) and Herpes genitalis (HG), the therapeutic window for treating HSV infections with antiviral drugs is narrow. It is important to recognize prodromal symptoms in patients and subsequently (self-)administer appropriate therapy. Clinical trials have shown that the shorter duration of higher doses of antiviral drugs, the more suitable and equally or even more effective results are obtained. According to the analysed literature, Acyclovir remains the most effective choice of treatment for the majority of patients. In some cases, other similar antiviral drugs could be effective when the treatment with Acyclovir fails to give the expected results.
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