Terapia szyta na miarę czyli jak poprawić skuteczność leczenia i rokowanie chorego. Intensyfikacja leczenia hipotensyjnego krok po kroku — od monoterapii do leków złożonych

Abstract

The goal of antihypertensive therapy is to reduce the risks associated with blood pressure (BP) elevation without adversely affecting quality of life. Drug selection is based on efficacy in lowering BP and in reducing cardiovascular end points including stroke, myocardial infarction, and heart failure. For patients with stage 1 hypertension, it is often reasonable to start with monotherapy. Recent data, however, suggest that the advantages of initial combination treatment may extend to stage 1 hypertension. Available data suggest that about 70–80% of patients will require combination therapy to achieve contemporary blood pressure targets. Rational combination therapy is based on the co-administration at least two antihypertensive agents. Perindopril-based single-pill combinations are associated with a significant improvement in compliance, effective blood pressure-lowering, and reduction long-term incidence of cardiovascular events.