Abstract
The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2- to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed.
Highlights
Brain gliomas are the most common and deadly malignant brain tumors.[1]
Embedding brain gliomas in paraffin is a widely used first step in microscopic pathology analysis owing to its better storage and long-term tissue morphology preservation in clinical settings.[4]
The experimental setup used in this study is a transmission THz time-domain spectroscopy (TDS) system (Fig. 1), whose THz emitter is a photoconductive antenna with an electrode distance of 50 μm
Summary
Brain gliomas are the most common and deadly malignant brain tumors.[1] Gliomas are the leading cause of death by brain diseases in both children and adults,[2] and the median survival for patients with brain gliomas is a mere 12 to 15 months.[3] An accurate, early clinical diagnosis of brain gliomas is crucial for patients’ treatment, in which microscopic pathology is the most commonly used technique for tissue analysis. Embedding brain gliomas in paraffin is a widely used first step in microscopic pathology analysis owing to its better storage and long-term tissue morphology preservation in clinical settings.[4] In addition, there are a large number of paraffin-embedded brain gliomas stored in medical institutions, which provide unique opportunities for later pathological studies. By excluding water, paraffin-embedded brain gliomas allow us to reveal the intrinsic properties of brain gliomas
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