Abstract
.Significance. One of the modern trends in medical diagnostics is based on metabolomics, an approach allowing determination of metabolites which can be the specific features of disease. High-resolution gas spectroscopy allows investigation of the gas metabolite content of samples of biological origin. We present the elaboration of a method of studying diabetic and non-diabetic biological samples, prepared as pellets, by terahertz (THz) high-resolution spectroscopy.Aim: The main idea of the work is studying the content of thermal decomposition gas products of diabetic and non-diabetic dried blood plasma and kidney tissues for revealing the set of gas-markers that characterized the diabetes by the THz high-resolution spectroscopy method.Approach: We present an approach to study the diabetic and non-diabetic blood plasma (human and rats) and kidney tissues (rats), using high-resolution spectroscopy based on the non-stationary effect of THz frequency range. The methods of preparing the blood and kidney tissue samples as pellets and of vaporizing the samples were developed.Results: The measurements of rotational absorption spectra of vapors at heating the pellets prepared from blood and kidney tissue were carried out in 118 to 178 GHz frequency range. The absorption lines appearing in spectra of the sample vapors were detected and identified. The molecular contents of thermal decomposition products differed for non-diabetic and diabetic samples; e.g., main marker is acetone appearing in the diabetic blood (human and rats) and in the diabetic kidney tissue.Conclusions: Our paper illustrates the potential ability for determining the metabolite content of biological samples for diagnostics and prognosis of diseases for clinical medicine.
Highlights
Nowadays, the problem of diagnostics of socially important diseases, including the early stage, attracts the great attention of scientific groups in the world.Journal of Biomedical OpticsDownloaded From: https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics on 08 Nov 2021 Terms of Use: https://www.spiedigitallibrary.org/terms-of-useApril 2021 Vol 26(4)Lykina et al.: Terahertz high-resolution spectroscopy of thermal decomposition gas products. . .One of the new approaches opening new possibilities in diagnostics and treatment of various diseases is metabolomics
Our paper illustrates the potential ability for determining the metabolite content of biological samples for diagnostics and prognosis of diseases for clinical medicine
Metabolomics is a field of science that investigates the final and intermediate metabolic products of a biological system
Summary
The problem of diagnostics of socially important diseases (diabetes, cancer diseases, etc.), including the early stage, attracts the great attention of scientific groups in the world.Journal of Biomedical OpticsDownloaded From: https://www.spiedigitallibrary.org/journals/Journal-of-Biomedical-Optics on 08 Nov 2021 Terms of Use: https://www.spiedigitallibrary.org/terms-of-useApril 2021 Vol 26(4)Lykina et al.: Terahertz high-resolution spectroscopy of thermal decomposition gas products. . .One of the new approaches opening new possibilities in diagnostics and treatment of various diseases is metabolomics. The problem of diagnostics of socially important diseases (diabetes, cancer diseases, etc.), including the early stage, attracts the great attention of scientific groups in the world. Lykina et al.: Terahertz high-resolution spectroscopy of thermal decomposition gas products. One of the new approaches opening new possibilities in diagnostics and treatment of various diseases is metabolomics. Metabolomics is a field of science that investigates the final and intermediate metabolic products of a biological system (cell, organs, or whole organism). The metabolomics can reveal the metabolites which can be the specific features of disease and can play a large role in diagnosis and prognosis for a disease. The media, containing the final and intermediate metabolic products in the human organism and useful for revealing the metabolites associated with diseases and pathologies, are exhaled breath, blood, urine, saliva etc
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