Abstract
The present work is aimed at studying the interactions of two cationic amphiphilic drugs, viz. imipramine hydrochloride (IMP) and promethazine hydrochloride (PMT), with several polymers (cationic, nonionic, and anionic) in aqueous solutions by using tensiometric and conductivity measurements. The onset of interaction, the so-called critical aggregation concentration (CAC), decreases on increasing the polymer concentrations whereas the critical micelle concentration (CMC) of the drugs rises. The strength of interaction was found to be dependent upon the nature of the polymers. The interaction between the anionic polymer NaCMC and drugs was maximum while it was minimum in case of drug–cationic polymer HECEQ system. The interfacial parameters like Gibbs surface excess (Γmax) and the minimum area occupied by the drug monomer (Amin) have been estimated. The free energies of adsorption (ΔGad0), aggregation (ΔGa0), micellization (ΔGm0) and transfer (ΔGt0) associated with the interactions between the drugs and polymers have also been evaluated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
