Abstract

The anti-curare action of Tensilon (3 hydroxy-phenyl dimethyl ethyl ammonium bromide) has been investigated. It was found that the effect of this drug, though apparently complete and permanent in experimental animals was somewhat evanescent in man. If complete decurarization was to be maintained in the human subject it was often necessary to give second or even third doses of Tensilon. Circulatory side-effects were slight when atropine was given with Tensilon. The conclusion is drawn that Tensilon, though free from the more serious muscarinic actions of neostigmine, is not as reliable an antidote to the muscle paralysing action of d-tubocurarine.

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